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Chung, Sungkwon, Ph. D., Associate Professor

Tel: +82-31-299-6103
Fax: +82-31-299-6129
e-mail: schung@yurim.skku.ac.kr
Date/Place of Birth: 14 September 1960, South Korea

Background:

1979 Mar - 1983 Feb: B.Sc. from Department of Chemistry, Seoul National University
1983 Mar - 1985 Feb: M.Sc from Department of Chemistry, Seoul National University
1986 Sep - 1991 Oct: Ph. D from Department of Biochemistry, Brandeis University (U.S.A.)
1991 Oct - 1994 Feb: Postdoctoral Fellow in Yale Medical School (U.S.A.)
1994 Mar - 1996 Feb: Research Fellow in Asan Life Science Institute, Seoul
1996 Mar - 1999 Aug: Assistant Professor in Department of Physiology, Chun-Ang University
1999 Sep - present: Assistant/Associate Professor in Department of Physiology,
Sungkyunkwan University School of Medicine

Research:

Roles of ion channels in neurodegenerative disease

The impaired activities of several ion channels are known to be associated with the development of neurodegeneraive diseases, such as Alzheimer’s disease. In order to investigate the physiological function of these ion channels, we measure the calcium signals and ion channel activities from several model cells.

Publications:

  1. Landman N, Serban G, Shin SY, Kang MS, Chung S*, Kim T-W* (2006) An essential role for phosphatidylinositol-4,5-bisphosphate in familial Alzheimer¡¯s disease-linked presenilin mutations. PNAS, in press. *co-corresponding authors
  2. Soon Youn Jeong, Sun Young Shin, Han-Seop Kim , Chang-Dae Bae, Dae-Yong Uhm, Myung-Kyu Park, Sungkwon Chung (2005) Regulation of Magnesium-Inhibited Cation Current by Actin Cytoskeleton Rearrangement. BBRC 339:810-815.
  3. Lee M, Chung S, Uhm DY, Park MK. (2005) Regulation of zymogen granule exocytosis by Ca2+, cAMP, and PKC in pancreatic acinar cells. BBRC 334(4) 1241-1247.
  4. Kim Y, Park MK, Uhm DY, Shin J, Chung S. (2005) Modulation of delayed rectifier potassium channels by alpha1-adrenergic activation via protein kinase C zeta and p62 in PC12 cells. Neurosci Lett. 14;387(1):43-8.
  5. D. Cooper, S. Chung, N. Spruston (2005) Output-mode transitions are controlled by prolonged inactivation of sodium channels in pyramidal neurons of subiculum. PLoS Biology 3:1123-1129.
  6. Kim Y, Uhm DY, Shin J, Chung S. (2004) Modulation of delayed rectifier potassium channel by protein kinase C zeta-containing signaling complex in pheochromocytoma cells. Neuroscience. 125:359-68.
  7. Kim SH, Choi YM, Chung S, Uhm DY, Park MK. (2004) Two different Ca2+-dependent inhibitory mechanisms of spontaneous firing by glutamate in dopamine neurons. J. Neurochem. 91:983-95.