Educational and Professional Experience:

Education
Columbia University, USA. Ph.D. in molecular biology (1994)
Columbia University, USA. M.S. in molecular biology (1991)
Seoul National University, Korea. M.D. (1983)

Professional

1997 - present:	Associate Professor, Professor, Sungkyunkwan University School of Medicine
1995 - 1997:	Assistant Professor, Seoul National University College of Medicine
1989 - 1994:	Research Fellow, Columbia University, USA
1987 - 1989:	Postdoctoral Associate, Whitehead Institute, MIT, USA

Research Interest:

1) Transcriptional regulation during hematopoietic cell differentiation
2) Pathogenesis of acute myeloid leukemia

Our team has been working on molecular mechanism of leukemic cell differentiation. We have recently shown that MEF2 transcription factor is required during HL60 promyelocytic cell differentiation and screened for differentially expressed genes during HL60 cell differentiation to monocytes. We are currently analyzed function of those genes in myelomonocytic cell differentiation and leukemogenesis

Representative Publications:

1. Park SY, Shin HM, Han TH. 2002. Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter. Mol Immunol. 39:25-30.
2. So-Jung Choi, So-Youn Park, and Tae-Hee Han. 2001.14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation. Nucleic Acids Reserach 29(13):2836-2842.
3. Shin, H.M., J. Y. Seoh, H. Y. Chung, S. J. Choi, M. J. Hahn, J. S. Kang, M. S. Choi, and T. H. Han. 1999. Requirement of MEF2D in the induced differentiation of HL60 promyeloid cells. Molecular Immunology 36:1209-1214.
4. Shin, H. M., and T. H. Han. 1999. CD28-mediated regulation of the c-jun promoter involves the MEF2 transcription factor in Jurkat T cells. Molecular Immunology 36: 197-203.
5. Tae-Hee Han, Ron Prywes. 1995. Regulatory role of MEF2D in serum induction of the c-jun promoter. Molecular and Cellular Biology 15:2907-2915.
6. Tae-Hee Han, William W. Lamph, and Ron Prywes. 1992. Mapping of epidermal growth factor-, serum-, and phorbol ester-responsive sequence elements in the c-jun promoter. Molecular and Cellular Biology 12:4472-4477.