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Kim, Sung Joon, Assistant Professor

Department of Physiology,
Sungkyunkwan University School of Medicine
Suwon, 440-746, KOREA
Tel: +82-31-299-6104, 6112
Fax: +82-31-299-6129
e-mail: sjoonkim@med.skku.ac.kr

Academic History:

1985. 3 - 1991. 2: Seoul National University College of Medicine, M.D.
1991. 3 - 1993. 2: Seoul National University, M.S. (Physiology)
1993. 3 - 1997. 2: Seoul National University, Ph.D. (Physiology)

Title of Ph.D. thesis -
Nonselective cationic current activated by muscarinic stimulation in guinea-pig gastric myocyte : electrophysiological-, pharmacological characteristics and Ca2+ dependent modulation. (Prof. Ki Whan Kim, Seoul National University College of Medicine)

Professional Background:

2000. 9 - present: Sungkyunkwan University School of Medicine, Assistant Professor
2000. 7.: Albert-Ludwig's University of Freiburg, Research Staff
1998. 8 - 2000. 6: Physiologisches Institut, Albert-Ludwig's University of Freiburg, Alexander von Humboldt Research Fellow (Mentor : Prof. Dr. Rainer Greger)
1995. 5 - 1998. 7: Seoul National University Medical Research Center, Research Fellow
1995. 2 - 1995. 4: Academy for Medical Officer
1991. 4 - 1995. 1: Seoul National University College of Medicine, Teaching Assistant

Professional Society:

The Korean Physiological Society
The Korean Biophysical Society

Current Research Interest: Laboratory of Cell Physiology

Main research interest of our laboratory include 1) Role of K+ channels in non-excitable cells and, 2) Exocytosis and its regulation in neuroendocrine cells. K+ channels in the exocrine gland (pancreas, salivary gland) and B-lymphocytes are currently investigated by using patch clamp techniques combined with fura-2 ratiometry for Ca2+ measurement. For the study of exocytosis, prostatic neuroendocrine cells are newly started to be investigated and will be compared with classical type of neuroendocrine cells (e.g. adrenal chromaffin cells). Both the capacitance measurement combined with patch clamp and the amperometry technique will be applied to single neuroendocrine cells. In addition, we are currently carrying out many projects in collaboration with other groups to reveal the functional changes of CFTR mutation in Korean people, to investigate the mechanism of apoptosis in immature B lymphocytes and pancreatic beta cells. Our laboratory is equipped with patch clamp systems, fura-2 Ca2+ measurement system, Ussing chamber apparatus, and basic molecular biology facilities.

Publication list:

International Journals

  1. Kim JH, Shin SY, Nam JH, Hong EK, Chung YS, Jeong JY, Kang JY, Uhm DY, Kim SJ. Adrenergic regulation of the intracellular [Ca2+] and voltage-activated Ca2+ channel currents in the rat prostate neuroendocrine cells. The Prostate submitted, 2003
  2. Nam JH, Yoon SS, Kim TJ, Uhm DY, Kim SJ. Slow and persistent increase of [Ca2+]c in response to ligation of surface IgM in WEHI-231 cells. FEBS Letters in press, 2003
  3. Kim JH, Shin SY, Yun SS, Kim TJ, Oh S-J, Kim KM, Cho HS, Hong E-K, Uhm D-Y, Kim SJ. Voltage-dependent ion channel currents in neuroendocrine cells of the rat prostate. Pflügers Arch in press. 2003
  4. Kim SJ, Shin SY, Lee JE, Kim JH, Uhm D-Y. Ca2+-activated Cl- channel currents in rat ventral prostate epithelial cells. The Prostate in press, 2003
  5. Lee JE, Kim JH, Choi SJ, Han T-H, Uhm D-Y, Kim SJ. Inhibitory effects of PGE2 on K+ currents and Ca2+ oscillation in rat pancreatic acinar cells. Pflügers Arch, 444:619-626, 2002
  6. Kim JH. Hong EK, Choi H, Oh SJ, Kim KM, Uhm DY, Kim SJ K+ channel currents in rat ventral prostate epithelial cells. The Prostate, 51:201-210, 2002.
  7. Warth R, Garcia-Alzamora M, Kim JK, Zdebik A, Nitschke R, Bleich M, Gerlach U, Bahranin J, Kim SJ. The role of KCNQ1/KCNE1 K+ channels in intestine and pancreas: Lessons from the KCNE1-knockout mouse. Pflügers Arch, 443:822-828, 2002
  8. Lehrmann H, Thomas J, Kim SJ, Leipziger J. Luminal P2Y2 receptor-mediated inhibition of Na+ absorption in isolated perfused mouse cortical collecting duct. J Am Soc Nephrol, 13:10-18, 2002
  9. Lee JE, Gerlach U, Uhm DY, Kim SJ. Inhibitory effect of somatostatin on the secretin-induced augmentation of the slowly activating K+ current (IKs) in the rat pancreatic acinar cells. Pflügers Arch. 443: 405-410, 2002
  10. Kim SJ, Kim JK, Pavenst_dt H, Greger R, Hug MJ, Bleich M. Regulation of slowly activating potassium current (IKs) by secretin in rat pancreatic acinar cells. J Physiol 535: 349-358, 2001
  11. Oh SJ, Kim SJ, Park EC, Chung HK, Kim KW, Choi H. Effects of local anesthetics on the contractility of rat urinary bladder. J Urol 165:2044-2050, 2001
  12. Kang TM, Kim YC, Sim JH, Rhee JC, Kim SJ, So I, Kim KW. The properties of carbachol-activated nonselective cation channels (NSCCCh) at single channel level in guinea-pig gastric myocytes. Jap J Pharmacol 85:291-298, 2001
  13. Sim JH, Kim YC, Kim SJ, Lee SJ, Suh SH, Jun JY, So I, Kim KW. Capsaicin inhibits the voltage-operated calcium channels intracellularly in the antral circular myocytes of guinea-pig stomach. Life Sciences 68:2347-2360, 2001
  14. Kim SJ, Kerst G, Schreiber R, Pavenst dt H, Greger R, Hug MJ, Bleich M. Inwardly rectifying K+ channels in the basolateral membrane of rat pancreatic acini. Pflügers Arch 441: 331-340, 2000
  15. Park SJ, Kim YC, Suh SH, Rhim H, Sim JH, Kim SJ, So I, Kim KW. Background nonselective cationic current and the resting membrane potential in rabbit aorta endothelial cells. Jpn J Physiol 50:635-643, 2000
  16. Oh SJ, Lee KH, Kim SJ, Kim KW, Kim KM, Choi H. Active properties of the urinary bladder: in vitro comparative studies between adult and neonatal rats. BJU Int 85: 1126-1133, 2000
  17. Deetjen P, Thomas J, Lehrerman H, Kim SJ, Leipziger, J. The luminal P2Y receptor in the isolated perfused mouse cortical collecting duct. J Am Soc Nephrol 11: 1798-1806, 2000
  18. Kim SJ, Greger R. Voltage-dependent, slowly activating K+ current (IKs) and its augmentation by carbachol in rat pancreatic acini. Pfluegers Arch 438: 604-611, 1999
  19. Koettgen M, Hoefer A, Kim SJ, Beschorner, Schreiber R, Hug MJ, Greger R. Carbachol activates a K+ channel of very small conductance in the basolateral membrane of rat pancreatic acini. Pfluegers Arch 438: 597-603, 1999
  20. Oh SJ, Ahn SC, Kim SJ, Kim KW, Lee A, Kim KM, Choi H. Carbachol-induced sustained tonic contraction of rat detrusor muscle. BJU Int 84: 343-349, 1999
  21. Kim SJ, Koh EM, Kang TM, Kim YC, So I, Isenberg G, Kim KW Ca2+ influx through carbachol-activated non-selective cation channels in guinea-pig gastric myocytes. J Physiol 513:749-760, 1998
  22. Kim JK, Kim SJ, Kim YC, So I, Kim KW. Influence of extracellular Na+ removal on cytosolic Ca2+ concentration in smooth muscle cells of rabbit cerebral artery. J Smooth Muscle Res 35: 135-145, 1999
  23. Kim SJ, Ahn JM, Kim YC, Park SJ, Choi JY, Suh SH, So I, Kim KW. Relationship between global cytosolic Ca2+ concentration and Ca2+-activated K+ current in rabbit cerebral arterial myocyte. J Smooth Muscle Res 34: 159-172, 1999
  24. Jun JY, Yeum CH, Yoon PJ, Chang IY, Kim SJ, Kim KW. ATP-sensitive K+ current and its modulation by substance P in gastric myocytes isolated from guinea pig. Eur J Pharmacol 358: 77-83, 1998
  25. Kim YC, Kim SJ, Sim JH, Cho CH, Juhnn YS, Suh SH, So I, Kim KW. Suppression of the carbachol-activated nonselective cationic current by antibody against alpha subunit of Go protein in guinea-pig gastric myocytes. Pfluegers Arch 436: 494-496, 1998
  26. Kim YC, Kim SJ, Sim JH, Jun JY, Kang TM, Suh SH, So I, Kim KW. Protein kinase C mediates the desensitization of CCh-activated nonselective cationic current in guinea-pig gastric myocytes. Pfluegers Arch 436: 1-8, 1998
  27. Kim SJ, Ahn SC, Kim JK, Kim YC, So I, Kim KW. Changes in intracellular Ca2+ concentration induced by L-type Ca2+ channel current in guinea-pig gastric myocytes. Am J Physiol 273: C1947-C1956, 1997
  28. Xu W, Kim SJ, Kang TM, Rhee JC, So I, Kim KW. Volume-sensitive chloride current activated by hyposmotic swelling in antral gastric myocytes of guinea-pig. Pfluegers Arch 435: 1-8, 1997
  29. Ahn SC, Kim YC, Kim SJ, So I, Kim KW. Inhibitory effect of phorbol 12, 13 dibutyrate on carbachol-activated nonselective cationic current in guinea-pig gastric myocytes. Pfluegers Arch 434: 505-507, 1997
  30. Xu W, Kim SJ, So I, Kim KW. Role of actin microfilament in the osmotic-stretch induced increase of voltage-operated calcium channel current gastric myocyte of guinea-pig. Pfluegers Arch 434: 502-504, 1997
  31. Kim YC, Kim SJ, Kang TM, Ahn SC, So I, Kim KW. Effect of myosin light chain kinase inhibitors on CCh-activated nonselective cationic current in guinea-pig gastric myocytes. Pfluegers Arch 434: 346-353, 1997
  32. Ahn SC, Kim YC, Kim SJ, So I, Kim KW. Dual roles of phorbol 12,13-dibutyrate in the regulation of guinea-pig gastric contraction. J Smooth Muscle Res 33:11-22, 1997
  33. Xu W, Kim Sung Joon, Kim Sang Jeong, Kang TM, Rhee JC, So I, Kim KW. Effect of stretch on calcium channel currents recorded from the antral circular myocytes of guinea-pig stomach. Pfluegers Arch 432:159-164, 1996
  34. Ahn SC, Kim YC, Kim SJ, So I, Kim KW. Effect of intracellular cAMP on K current in single gastric myocytes of guinea-pig. J Smooth Muscle Res 31: 411-413, 1995
  35. Kim SJ, Ahn SC, So I, Kim KW. Role of calmodulin in the activation of carbachol-activated cationic current in guinea-pig gastric antral myocytes. Pfluegers Arch 430: 757-762, 1995
  36. Kim SJ, Ahn SC, So I, Kim KW. Quinidine blockade of the carbachol-activated nonselective cationic current in guinea-pig gastric myocytes. Br J Pharmacol 115: 1407-1414, 1995

Domestic Journals

  1. Koh TY, Kim SJ, Lee SJ, Kang TM, Jun JY, Sim JH, So I, Kim KW. Neurotensin enhances gastric motility in antral circular muscle strip of guinea-pig. Kor J Physiol Pharmacol 4: 227-234, 2000
  2. Kang TM, Xu W, Kim SJ, Ahn SC, Kim YC, So I, Park MK, Uhm DY, Kim KW. Evidence for adenosine triphosphate (ATP) as an excitatory neurotransmitter in guinea-pig gastric antrum. Kor J Physiol Pharmacol 3: 165-174, 1999
  3. Kim DH, Kim SJ, Lee SJ, Park SJ, Kim KW. Moderate elevation of extracellular K+ concentration induces vasorelaxation in isolated rat, rabbit and human cerebral arteries: role of Na+ pump and Ba2+-sensitive process. Kor J Physiol Pharmacol 2: 705-714, 1998
  4. Suh SH, Park SJ, Choi JY, Sim JH, Kim YC, Kim SJ, So I, Kim KW. Sensitivity of rabbit cerebral artery to serotonin is increased with the moderate increase of extracellular K+. Kor J Physiol Pharmacol 2: 695-703, 1998
  5. Kim JY, Kim SJ, Kang TM, Lee SJ, So I, Kim KW. Effects of prostaglandin E2 on the spontaneous contractions and electrical activities of the antral circular muscle in guinea-pig stomach. Kor J Physiol Pharmacol 2: 361-368, 1998
  6. Kim SJ, Min KW, Kim YC, Lee SJ, So I, Kim KW. Inhibitory effect of caffeine on carbachol-induced nonselective cationic current in guinea-pig gastric myocytes. Kor J Physiol Pharmacol 2: 353-359, 1998
  7. Kim JK, Kim SJ, Kim YC, So I, Kim KW. Characteristics of Ca2+ stores in rabbit cerebral artery myocytes. Kor J Physiol Pharmacol 2: 313-322, 1998
  8. Jun JY, Yeum CH, Yun PJ, Park JS, Kim SJ, So I, Kim KW. ATP-sensitive K+ currents in gastric myocytes isolated from guinea-pig. Kor J Physiol Pharmacol 2: 85-93, 1998
  9. Xu W, Kim SJ, So I, Kim KW. Effects of arachidonic acid on the calcium channel current (IBa) and on the osmotic stretch-induced increase of IBa in guinea-pig gastric myocytes. Kor J Physiol Pharmacol 1: 435-441, 1997
  10. Kim CS, Jun JY, Kim SJ, So I, Kim KW. Contractile and electrical responses of guinea-pig gastric smooth muscle to bradykinin. Kor J Physiol 29(2): 233-241, 1995
  11. Ahn JM, Ahn SC, Choi YB, Kang TM, Kim SJ, So I, Kim KW. The possible role of nitric oxide on enteric nerves-mediated relaxation of the gastric smooth muscle of the guinea pig. Seoul J Med 35(1): 1-8, 1994.
  12. Kim SJ, Jun JY, Choi YB, Kim KW, Kim WG. Effects of lemakalim, a potassium channel opener, on the contractility and electrical activity of the antral circular muscle in guinea-pig stomach. Kor J Physiol 28(1): 37-50, 1994.
  13. Jun JY, Kim SJ, Choi YB, Kim KW. The excitatory mechanism of substance P in the antral circular muscle of guinea pig stomach. Kor J Physiol 28(1): 51-59, 1994
  14. Rhee PL, Lee SJ, Kim SJ, So I, Hwang SI, Kim KW. Effect of dopamine on the Ca-dependent K currents in isolated gastric myocytes of the guinea-pig. Kor J Physiol 27(2): 139-150, 1993.
  15. Jun JY, Lee SJ, Suh JY, Kim SJ, So I, Hwang SI, Kim KW. Effects of noradrenaline on the spontaneous contractions and ionic currents in the antral circular muscle of guinea-pig stomach. Korean J Physiol 27(2): 115-122, 1993.
  16. Kim SJ, Lee SJ, Yun BC, Kim KW. Effects of prostaglandin F2_ on the spontaneous contractions and electrical activities in the circular smooth muscle of the guinea-pig stomach. Seoul J Med 34(2): 83-97, 1993.