>> go to faculty list
>> go to Department of Molecular Cellular Biology
Kim, Seong-Tae, Assistant Professor

Tel: +82-31-299-6137
Fax: +82-31-299-6149
e-mail: stkim@med.skku.ac.kr
Date/Place of Birth: 1 August 1964, South Korea

Background:

1984 Mar - 1988 Feb: B.S from Department of Microbiology, Seoul National University
1988 Mar - 1990 Feb: M.S from Department of Microbiology, Seoul National University
1990 Mar - 1996 Feb: Ph.D from Department of Microbiology, Seoul National University
1996 Sep - 1998 Aug: Postdoctoral fellow, Department of Biochemistry, School of Public Health and Hygiene, The Johns Hopkins University, USA
1998 Sep - 2001 Aug: Postdoctoral fellow, Department of Hematology/Oncology, St. Jude Children’s Research Hospital, USA
2001 Sep – Present: Assistant Professor, Department of Molecular Cellular Biology, Sungkyunkwan University School of Medicine

Research:

Maintenance of genomic integrity requires a complex network of defense mechanisms. In response to DNA damage, eukaryotic cells activate cell cycle checkpoint and DNA repair mechanisms. The inactivation of many of the genes involved in DNA damage response pathway leads to various disorders and enhanced rates of cancer development.

We are interested in how cells sense and respond to stress in the form of damage to their genetic material. When cells incur DNA damage or under go DNA replication interference, they arrest the cell cycle via cell cycle checkpoint pathways and induce the transcription of genes involved in repair of the damage. Failure to do this can result in genomic instability and cancer in humans. To investigate how cells responsd to DNA damage, we identified various novel checkpoint genes and is working on their functions and regulations.

Publications:

  1. Xu B, O'Donnell AH, Kim ST, Kastan MB (2002) Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. Cancer Research 62, 4588-91.
  2. Taniguchi T, Garcia-Higuera I, Xu B, Andreassen PR, Gregory RC, Kim ST, Lane WS, Kastan MB and D'Andrea AD (2002) Convergence of the Fanconi Anemia and Ataxia Telangiectasia signalling pathways. Cell 109, 459-472
  3. Kim ST, Xu B and Kastan MB (2002) Involvement of the Cohesin Protein, SMC1, in an ATM-dependent Response to DNA Damage. Genes & Development 16, 560-570. *Cover story
  4. Xu B, Kim ST, Lim DS and Kastan MB (2002) Two Molecularly Distinct G2/M Checkpoints Are Induced by Ionizing Irradiation. Mol. Cell. Biol. 22, 1025-1035.
  5. Maya R, Balass M, Kim ST, Buschmann T, Shifman O, Shkedy D, Shiloh Y, Ronai Z, Kastan MB, Katzir E and Oren M. (2000) ATM-dependent Phosphorylation of MDM2 on Serine 395: role in p53 activation by DNA damage. Genes & Development 15, 1067-1077. *Cover Story
  6. Bo X, Kim ST and Kastan MB. (2001) Requirements of Brca1 in S-phase and G2-phase checkpoints. Mol. Cell. Biol. 21, 3445-3450.
  7. Kastan MB, Lim DS, Kim ST, and Yang D. (2001) ATM: A Key determinant of multiple cellular responses to irradiation. Acta Oncologica 40, 686-8.
  8. Huh WK, Kim ST, Lee H and Kang SO. (2001) Deficiency of D-Erythroascorbic Acid Attenutates Hyphal Growth and Virulence of Candida albicans. Infection and Immunity 69, 3939-46.
  9. Lee JS, Huh WK, Lee BH, Baek YU, Hwang CS, Kim ST, Kim YR, and Kang SO. (2001) Mitochondrial NADH-cytochrome b5 reductase plays a crucial role in reduction of D-erythroascorbyl free radical in Saccharomyces cerevisiae. Biochim. Biophys. Acta 25180, 1-8.
  10. Kastan MB, Lim DS, Kim ST, Xu B and Canmann C. (2000) Multiple signalling pathways involving ATM. Cold Spring Harbor Quant. Biol. 65, 521-526.
  11. Kim ST*, Lim DS, Xu B, Maser RS, Lin J, Petrini P and Kastan MB. (2000) ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 404, 613-617. *equally contributed.
  12. Kim ST, Lim DS, Canmann C, and Kastan MB. (1999)Substrate specificities and Identification of ATM kinase family Members. J. Biol. Chem. 274, 37538-37543.
  13. Kastan MB, Lim DS., Kim ST, and Canman CE. (1999) Roles of TP53 and ATM in Radiation Responses. Radiation Research Vol II, 413-415
  14. Lee BH, Huh WK, Kim ST, Lee JS, and Kang SO. (1999) Bacterial production of D-erythroascorbic acid and L-ascorbic acid through functional expression of Saccharomyces cerevisiae D-arabinono- 1,4-lactone oxidase in Escherichia coli. Appl Environ Microbiol 65, 4685-4687.
  15. Hwang CS, Rhie GE, Kim ST, Kim YR, Huh WK, Baek YU, and Kang SO. (1999). Copper- and zinc-containing superoxide dismutase and its gene from Candida albicans. Biochim. Biophys. Acta 1427, 245-255.
  16. Rhie GE, Hwang CS, Brady MJ, Kim ST, Kim YR, Huh WK, Baek YU, Lee, BH, Lee JS and Kang SO. (1999). Manganese-containing superoxide dismutase and its gene from Candida albicans. Biochim. Biophys. Acta 1426, 409-419.
  17. Kim ST, Huh WK, Lee BH and Kang SO. (1998). D-arabinose dehydrogenase and its gene from Saccharomyces cerevisiae. Biochim. Biophys. Acta 1429, 29-39.
  18. Huh WK, Lee BH, Kim ST, Kim YR, Rhie GE, Baek YW, Hwang CS, Lee JS and Kang SO. (1998). D-Erythroascorbic acid is an important antioxidant molecule in Saccharomyces cerevisiae. Mol. Microbiol. 30, 895-903.
  19. Kim ST, Huh WK, Kim JY, Hwang SW and Kang SO. (1996). D-arabinose dehydrogenase and biosynthesis of erythroascorbic acid in Candida albicans. Biochim. Biophys. Acta 1297, 1-8.
  20. Seok YJ, Kim ST, Yang KS, Huh WK and Kang SO. (1996). Characterization of Enediol-Containing Tautomers of L-Xylosone. J. Carbohydrate Chemistry 15, 1073-1083.
  21. Seok YJ, Yang KS, Kang JK, Kim ST, Huh WK and Kang SO. (1996). Detection of L-Xylosone and its Physiological Effects in Saccharomyces cerevisiae. J. Microbiol. 34, 192-197.
  22. Seok YJ, Yang KS, Kim ST, Huh WK and Kang SO. (1996). Characterization of Quinoxaline Derivatives of Dehydro-D-Erythroascorbic Acid. J. Carbohydrate Chemistry 15, 1085-1095
  23. Kim ST, Yang KS, Seok YJ, Huh WK and Kang SO. (1994). Purification and Characterization of Glyoxalase I from Pleurotus ostreatus. Kor. J. Microbiol. 32, 315-321.
  24. Huh WK, Kim ST, Yang KS, Seok YJ, Hah YC and Kang SO. (1994). Characterisation of D-arabinono-1,4-lactone oxidase from Candida albicans ATCC 10231. Eur J Biochem. 225, 1073-9.
  25. Kim JY, Kim ST, Kang SO and Min KH. (1994). Partial Purification of Catechol 1,2-Dioxygenase from Pseudomonas putida SM 25 and Production of cis,cis-Muconic acid by the purified enzyme. Kor. J. Microbiol. 32, 409-416.

Patents:

  1. Kastan MB, Canman C, Kim ST, Lim DS. (2002) ATM kinase modulation for Screening and Therapies. USA, Patent Number: 6,348,311.
  2. Kastan MB, Canman C, Kim ST, Lim DS. (2002) ATM kinase modulation for Screening and Therapies. USA, Patent Number: 6,387,640.