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Lee, Han-Woong, Ph.D., Associate Professor

LABORATORY OF MAMMALIAN MOLECULAR GENETICS > lab homepage
Tel: +82-31-299-6135 (Office), 6425 (Administrator), 6427-30 (Lab)
Fax: +82-31-299-6435
e-mail: hwl@med.skku.ac.kr
Date/Place of Birth: 14 March 1959, Korea

Education:

Mar. 1977 - Feb. 1981: Yonsei University, Seoul, Korea. B. S. in Biochemistry
Mar. 1981- Feb. 1983: Yonsei University, Seoul, Korea. M. S. in Biochemistry
Jul. 1991 - Jan. 1994: Albert Einstein College of Medicine, New York, U.S.A.
M. S. in Microbiology and Immunology
Jul. 1991- Jan. 1997: Albert Einstein College of Medicine, New York, U.S.A.
Ph.D. in Microbiology, Immunology, and Molecular Genetics
(Thesis: Molecular Genetic analysis of the INK4a Gene Products and Telomerase RNA Component in vivo. Thesis Advisor: Ronald A. DePinho, M.D.)

Experiences:

Jun. 1983 - Feb. 1985: Research Assistant, Dept. of Pharmacology
Yonsei University School of Medicine, Korea
Feb. 1986 - Jun. 1991: Senior Research Assistant, Dept. of Biochemical Immunogenetics, Memorial Sloan-Kettering Cancer Center, New York (Advisor: Soo Young Yang, Ph.D.)
Jan. 1997 - Feb. 1997: Postdoctoral Fellow, Dept. of Microbiology and Immunology
Albert Einstein College of Medicine, New York, U.S.A.
Mar. 1997 - Feb. 1998: Research Associate, Dept. of Microbiology and Immunology
Albert Einstein College of Medicine, New York, U.S.A.
Mar. 1998 - Feb. 1999: Assistant Professor, Dept. of Biochemistry & Molecular Biology
Seoul National University College of Medicine, Seoul, Korea
Mar. 1998 - Feb. 1999: Scientific Consultant, Macrogen Inc.
Feb. 1999 - Present: Staff Scientist, Center for Molecular Medicine
Samsung Biomedical Research Institute, Seoul, Korea
Sep. 1999 - Present: Assistant Professor, Associate Professor, Dept. of Molecular Cell Biology
Sungkyunkwan University School of Medicine, Suwon, Korea
Mar. 2001 - Present: Principal Investigator, Team of Production and Funtional
Analysis of Genetically Modified Mice
The 21st Century Frontier Program in Functional Human Genome Project.
Jul. 2002 - Present: Principal Investigator, Mammalian Molecular Genetics Laboratory
National Research Laboratory
Ministry of Science and Technology, Korea.
Apr. 2003 - Present: Associate Director, Laboratory Animal Research Center
Sungkyunkwan University School of Medicine, Suwon, Korea

Research Interests:

Our laboratory uses mouse molecular genetics (transgenic and knockout technologies) and genomics to dissect the molecular mechanisms and biological processes governing the genesis and maintenance of tumorigenesis and senescence. Analyses of the telomerase and its related proteins have focused on the physical and functional interactions among them and how these interactions regulate gene expression and its activity and thereby control the mechanism of normal, ageing and neoplastic cells.
From the view of telomerase, we have also been producing various mouse models to elucidate the mechanism of several related human genetic diseases. Currently, a novel function of telomerase has been discovered in our laboratory and being studied extensively. We have also discovered several novel genes that regulate telomerase activity and thereby control senescence and immortalization.

Publications:

  1. Lee, H.-W. Malonate Transport by Pseudomonas fluorescens. Thesis for Master of Science, Department of Biochemistry, College of Science, Yonsei University, Seoul, Korea, Feb. 21, 1983.
  2. Lee, C. I.,H.-W. Lee, W. J. Kim. The studies on Isoenzymes in pancreatic juice by isoelectric focusing. Yonsei J. Med. Sci. 17(1):182-192, 1984.
  3. Mizuno, S., S. H. Kang,H.-W. Lee, B. Dupont, S. Y. Yang. Isolation and expression of a cDNA clone encoding an HLA-Cw6: Unique characteristics of HLA-C encoded gene products. Immunogenetics 29:323-330, 1989.
  4. Park, J. H., H.-W. Lee, K. Fleischhauer, C. G. Kim, M. Sheffery, S. Y. Yang. DNA binding proteins for transcription enhancing region of HLA class I gene. Tissue Antigen 42:782-786, 1993.
  5. Chin, L., N. Schreiber-Agus, I. Pellicer, K. Chen, H.-W. Lee, M. Dudast, C. Cordon-Cardo, and R. A. DePinho. Contrasting roles for Myc and Mad proteins in cellular growth and differentiation. Proc. Natl. Acad. Sci. U. S. A. 92:8488-8492, 1995.
  6. Lee, H.-W. and R. A. DePinho. Analysis of myc Function by Gene Disruption. Einstein Quart. J. Biol. Med. 12(2): 55, 1995.
  7. Bali, D., A. Svetlanov, H.-W. Lee, D. Fusco-DeMane, M. Leiser, B. Li, N. Barzilai, M. Surana, H. Hou, N. Fleischer, R. A. DePinho, L. Rossetti, and S. Efrat. Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J. Biol. Chem. 270(37): 21464-21467, 1995.
  8. Lee, H.-W.*, M. Serrano*, L. Chin, C. Cordon-Cardo, D. Beach, R. A. DePinho. Role of the INK4a locus in tumor suppression and cell mortality. *Contributed equally. Cell 85: 27-37, 1996.
  9. Hatton, K., K. Mahon, L. Chin, F.-C. Chiu, H.-W. Lee, D. Peng, S. D. Morgenbesser, J. Horner, R. A. DePinho. Expression and activity of L-Myc in normal mouse development. Mol. Cell Biol. 16(4):1794-1804, 1996.
  10. Lee, H.-W. Study of a tumor suppressor gene by gene targeting: p16INK4a. Korean Soc. Med. Biochem. Mol. Biol. News 3(6):19-22, 1996.
  11. Pomerantz, J., N. Schreiber-Agus, N. Liegeois, H.-W. Lee, A. Tam, K. P. Olive, R. A. DePinho, L. Chin. The role for INK4a in melanoma pathogenesis. One gene - two products - multiple pathways. in The Biology of Tumors. E. Mihich and C. Croce (eds.) Plenum Publishing, New York, 1997.
  12. Blasco, M. A. H.-W. Lee, M. Rizen, D. Hanahan, R. DePinho, C. W. Greider. Mouse models for the study of telomerase. in "Telomeres and telomerase". Ciba Found Symp 211: 160-170, 1997.
  13. Lee, H.-W.*, M. A. Blasco*, M. P. Hande, E. Samper, P. M. Landsdorp, R. A. DePinho, C. W. Greider. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. *Contributed equally. Cell 91:25-34, 1997, Cover Story.
  14. Lee, H.-W. Deciphering human cellular language: Elucidation of human birth process. Organizing and analysing the column by Nicholas Wade. Munhwa Daily News pp.15 Dec. 28, 1998.
  15. Pomerantz, J., N. Schreiber-Agus, Liegeois, N., A. Silverman, L. Alland, L. Chin, J. Potes, K. Chen, I. Orlow, H.-W. Lee, C. Cordon-Cardo, R. A. DePinho. The Ink4a tumor suppressor gene product, p19ARF, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 92: 713-723, 1998.
  16. Schreiber-Agus, N., Y. Meng, T. Hoang, H. Hou, Jr., R. Greenberg, C. Cordon-Cardo, H.-W. Lee, R. A. DePinho. Role of Mxi-1 in ageing organ systems and the regulation of normal and neoplastic growth. Nature 393: 483-487, 1998.
  17. Lee, H.-W., M. A. Blasco, J. Horner, G. J. Gottlieb, C. W. Greider, R. A. DePinho. Essential role of telomerase in highly proliferative organs. Nature, Article 392:569-574, 1998.
  18. Lee, H.-W. Study tumor suppressor genes by gene targeting: p16INK4a. Trend Med Res. 1: 116-119, 1998.
  19. Lee, H.-W. Essential role of telomerase in highly proliferative organs. Proc. Kor. Assoc. Mol. Cancer Res., 4: 23-30, 1998.
  20. Radfar, A., I. Unnikrishnan, H.-W. Lee, R. A. DePinho, N. Rosenberg. p19ARF induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation. Proc. Natl. Acad. Sci., U. S. A. 95: 13194-13199, 1998.
  21. Rudolph, K. L., S. Chang, H.-W. Lee, M. Blasco, G. Gottlieb, C. Greider, R. A. DePinho. Longevity, stress response, and cancer in aging telomerase deficient mice. Cell 96(5): 701-712, March 1999.
  22. Lee, H.-W., C. Cheong. Conditional gene targeting. Mol. Biol. News, The Korean Society of Molecular Biology. 11(2): 16-19, June 1999.
  23. Herrera, E., E. Samper, J. Martin-Caballero, J. M. Flores, H.-W. Lee, M. A. Blasco. Diseases states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 18(11): 2950-2960, June 1999.
  24. Shen-Li, H., R. C. O'Hagan, H. Hou, Jr., J. Horner, H.-W. Lee, R. A. DePinho. Essential role for Max in early embryonic growth and development. Genes & Dev. 14: 17-22, January 2000.
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  27. H.-W. Lee. Genetically engineered mice: in vivo model system. J. Kor. Diabetes Assoc. 24(3): 129 - 131, 2000.
  28. Shim, J, H.-S. Park, M. J. Kim, J. Park, E. Park, S. G. Cho, H.-W. Lee, C. O. Joe, E.-J. Choi. Rb protein down-regulates the stress-activated signals through inhibiting c-Jun N-terminal kinase/stress-activated protein kinase. J. Biol. Chem. 275: 14107-14111, May 2000.
  29. H.-W. Lee. Mouse in functional genomics. Mol. Biol. News, The Korean Society of Molecular Biology. 12(1): 16-19, March 2000.
  30. J. S. Park, S. Y. Hong, B. J. Jang, H. -W. Lee, M. J. Lee, K. J. Lee, S. S. Han, J. S. Han. A new guideline for the care of laboratory animals in transit in Korea. Kor. J. Lab. Anim. Sci. 16(4): 307-316, December 2000.
  31. Goodwin, E. C., E. Yang, C.-J. Lee, H.-W. Lee, D. DiMaio, E. -E. Hwang. Rapid induction of senescence in human cervical carcinoma cells. Proc. Natl. Acad. Sci., U. S. A. 97(20): 10978-10983, September 2000.
  32. H.-W. Lee. Cellular (Replicative) senescence: Telomerase. Kor. J. Gerontol. 10(1): 42 - 45, 2000.
  33. Fang, M. Z., D. Kim, H.-W. Lee, M. H. Cho, Improvement of In Vitro Two- Stage Transformation Assay and Determination of the Promotional Effect of Cadmium, Toxicology In Vitro, 15(3): 225-231, June 2001.
  34. Han, S., H. Choi, D. H. Son, J. K. Kim, H.-W. Lee, J.-B. Kim, S. D. Park, R. H. Seong. Peripheral T cells become sensitive to glucocorticoids- and stress-induced apoptosis in transgenic mice overexpressing SRG3. J. Immunol. 167: 805-810, July 2001.
  35. Choi, Y. I., S. H. Jeon, S. Han, J. Jang, H.-W. Lee, H.-Y. Chung, S. D. Park, R. H. Seong. Notch1 confers developing thymocytes a resistance to glucocorticoid induced apoptosis by Down-regulating SRG3 expression. Proc. Natl. Acad. Sci., U. S. A. 98(18): 10267-10272, August 2001.
  36. Cheong, C., H.-W. Lee. Telomerase: Unraveling our ends. The biochemical society of the republic of Korea. Biochem. News 21(3): 194-198, September 2001.
  37. Kim, J. K., S. Huh, H. Choi, K. Lee, D. Shin, C. Lee, J. Nam, H. Kim, H. Chung, H.-W. Lee, S. D. Park, R. H. Seong. Srg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development. Mol. Cell. Biol. 21(22): 7787-7795, October 2001.
  38. Kim, S.-W. C. Cheong, Y.-C. Sohn, Y.-H. Goo, W. J. Oh, J. H. Park, S. Y. Joe, H.-S. Kang, D.-K. Kim, C. Kee, J. W. Lee, H.-W. Lee. Multiple developmental defects derived from impaired recruitment of ASC-2 to nuclear receptors in mice: Implication for posterior lenticonus with cataract. Mol. Cell. Biol. 22(24): 8409-8414, 2002.
  39. Zhang Z., Y. Wang, C. R. Herzog, G. Liu, H-W. Lee, R. A. DePinho, M. You. A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression. Oncogene 29;21(38):5960-6, August 2002.
  40. Kim, B. J., M. S. Kim, K. B. Kim, K. W. Kim, Y. M. Hong, H.-W. Lee, Y. K. Jung. Sensitizing effects of cadmium on TNF-alpha- and TRAIL-mediated apoptosis of NIH3T3 cells with distinct expression patterns of p53. Carcinogenesis 23(9): 1411-1417, September 2002.
  41. Yang, E. Y., Y. H. Sung, H. -W. Lee. Telomerase: A Key to mortal or immortal road. Immune Network 2(4): 183-188, December 2002.
  42. Gwag, B. J. and H. -W. Lee. Telomerase prevents ischemic injury and NMDA neurotoxicity. Kor. J. Gerontol. 12(2): 47-52, 2002.
  43. Cheong, C., K. W. Hong, H. -W. Lee. Mouse models for telomere and telomerase biology. Exp. Mol. Med. 35(3): 141-153, July 2003.
  44. Y. S. Choi, S. B. Hong, H. K. Jeon, E. J. Kim, W.-J. Oh, S.-Y. Joe, H.-W. Lee. Insertional Mutation in the Intron 1 of Unc5h3 Gene Induces Ataxia, Growth Retardation and Hyperactivity in mice. Exp. Animals 52(4): 273-283, July 2003.
  45. Lee, S.-H., J. Kim, H.-W. Lee, Y.-S. Cho, S.-H. Oh, C. Cheong, W. Zhang, J. H. Lee. Interferon regulatory factor-1 (IRF-1) is a mediator for interferon-induced attenuation of telomerase activity and human telomerase reverse transcriptase (hTERT) expression. Oncogene 22(3):381-391, Jan. 2003.
  46. H. -W. Lee. The Golden Mice. The Science and Technology pp22-25, June 2003.
  47. Gibson, S. L., C. Y. Dai, H.-W. Lee, R. A. DePinho, M. S. Gee, W. M. F. Lee, E. E. Furth, C. Brensinger, G. H. Enders. Inhibition of Colon Tumor Progression by the Ink4a/Arf Locus. Cancer Research 63(4):742-746, Feb. 2003.
  48. Kim, T. Y., K. H. Lee, S. Chang, C. Chung, H.-W. Lee, J. Yim, T. K. Kim. Oncogenic potential of a dominant negative mutant of IRF3. J. Biol. Chem. 278(17): 15272-8, Apr 25, 2003.
  49. Djojosubroto, M. W., Y. S. Choi, H. -W. Lee, K. L. Rudolph. Telomeres and Telomerase in Aging, Regeneration and Cancer. Mol. Cells 15(2):164-175, April 30, 2003.
  50. D'Amico, M., K. Wu, D. Di Vizio, A. T. Reutens, M. Stahl, M. Fu, C. Albanese, R. G. Russell, W. J. Muller, M. White, A. Negassa, H. -W. Lee, R. A. DePinho, R. G. Pestell. The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis. Cancer Research 63(12): 3395-3402, Jun 15, 2003.
  51. Kim, M. J., B. -J. Park, Y. -S. Kang, H. J. Kim, J. -H. Park, J. W. Kang, S. W. Lee, J. M. Han, H. -W. Lee, S. Kim. Downregulation of fuse-binding protein and c-myc by tRNA synthetase cofactor, p38/JTV-1, for lung differentiation. Nature Genetics 34(3):330-336, July 2003.
  52. Kim, D. W., B. S. Kim, H. -S. Kwon, C. G. Kim, H.-W. Lee, W. H. Choi, C. G. Kim. Atrophy of brown adipocytes in the adult mouse causes transformation into white adipocyte-like cells. Exp. Mol. Med. 35(6): 518-526, 2003.
  53. H. -W. Lee. Gold-laying Mouse. Bio-Medical Science 1(1): 26-29, 2003.
  54. Jung, K. C., W. S. Park, E. Y. Choi, H. -W. Lee, Y. Bae. TCR-independent And Caspase-independent Apoptosis of Murine Thymocytes by CD24 Cross-linking. J. Immunol. 172(2): 795-802, January 15, 2004.
  55. Sung, Y. H., J. Song, H.-W. Lee. Functional Genomics Approach using Mouse. J. Biochem. Mol. Biol., 37(1): 122-132, January 2004.
  56. Kang, H. J., Y. S. Choi, S.-B. Hong, S. J. Won, E. J. Kim, H. K. Jeon, S.-Y. Jo, T. K. Kim, R. Bachoo, I. J. Reynolds, B. J. Gwag, H.-W. Lee. Ectopic expression of the catalytic subunit of telomerase protects against brain injury due to ischemia and N-methyl-D-aspartate-induced neurotoxicity. J. Neurosci. 24(6):1280-1287, February 11, 2004.
  57. Shin, K.-J., H.-H. Kim, D. Kim, Y.-H. Kim, H.-W. Lee, Y.-S. Chang, M.-B. Gu, S. H. Ryu, P.-G. Suh. 2,2',4,6,6'-Pentachlorobiphenyl induces mitotic arrest and p53 activation. Toxicol. Sci. 78: 215-221, April 2004.
  58. Chung, H. K., C. Cheong, J. Song, H.-W. Lee. Extratelomeric Functions of Telomerase. Curr. Mol. Med. 5: 233-241, March 2005.
  59. Sung, Y. H., J. Park, B. Choi, J. Kim, C. Cheong, Y. S. Choi, E. Y. Yang, M. Lee, J. S. Han, S. C. Park, T.-H. Han, T. J. Kim, J. Song, K. Rhee, H.-W. Lee. Hematopoietic malignancies associated with increased Stat5 and Bcl-xL Expression in Ink4a/Arf-deficient mice. Mech. Aging Dev. 126(6-7):732-739, May 2005.
  60. Tanemura, K., A. Ogura, C. Cheong, H. Gotoh, K. Matsumoto, E. Sato, Y. Hayashi, H. -W. Lee, T. Kondo. Dynamic rearrangement of telomeres during spermatogenesis in mice. Devel. Biol. 281(2):196-207, May 15, 2005.
  61. Sung, Y. H., Y. S. Choi, C. Cheong, H. -W. Lee. The pleiotropy of telomerase against cell death. Mol. Cells 19(3): 303-309, June 2005.