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Ro, Jai Youl, Professor

Tel: :+82-31-299-6191
Fax: +82-31-299-6209
e-mail: jyro426@med.skku.ac.kr
Date/Place of Birth: 20 October 1948, South Korea

Background:

1969 Mar - 1973 Feb:

BS from College of Pharmacy, Ewha Women University

1974 Mar - 1976 Feb:

MS from College of Pharmacy, Ewha Women University

1977 Mar - 1980 Feb:

Ph D from College of Pharmacy, Sungkyunkwan University

1985 Aug - 1987 Jan:

MA/Ph D (course work) from Department of Pharmacology,
University of Wisconsin-Madison, USA

1973 Mar - 1980 May:

Instructor in the dept. of Pharmacology, College of Medicine
Yonsei University

1980 Aug - 1985 May:

Postdoctoral Fellow, Fels Research Institute, School of Medicine
Temple University-Philadelphia, USA

1985 Aug - 1989 Feb:

Assistant Fellow in the dept. of Allergy & Immunology, School of Medicine, Univ. of Wisconsin-Madison, USA

1989 Mar - 2000 Feb:

Assistant/ Associate/ Professor in the dept. of Pharmacology, College of Medicine, Yonsei University

2000 Mar – Present:

Professor in the department of Molecular& Cellular Biology, Sungkyunkwan University School of Medicine

Research:

FceRI-dependent or Agonist-stimulated Signal Transduction in Mast Cells

Allergic diseases such as asthma are known to be caused by activation of mast cells, basophils, and eosinophils, and by imbalance of Th1 and Th2 cell environments. In our laboratory, we use the variety of mast cells such as guinea pig lung mast cells, human mast cell line (HMC-1), umbilical cord blood-derived mast cells, and mouse bone marrow-derived mast cells (BMMCs), which play a role of effector cell in the early phase and late phase of allergic diseases. When the mast cells are activated with antigen-antibody reaction or agonists, the various enzymes and second messengers in the cell membrane and cytosol are activated and signal transduction are proceeded. However, the mechanism of pathophysiology in the allergic diseases is not completely known. We suspect that MAP kinases, PI3 kinases, and Rac etc are associated to signal transduction. Therefore, our laboratory tries to examine the mechanism of pathophysiology in allergic diseases such as asthma using various mast cells or animal model, and then to develop the new drugs for these diseases. More detailed researches of our laboratory are as follows:

  1. To examine the signal transduction in the HMC-1 cells stimulated with IFN-g which is known as the type I cytokine and as down-regulator of the mast cells activated by IFN-g using western blot and RT-PCR.
  2. To examine the expressions and functions of proteins related to the granule generation in the HMC-1 cells activated with PMA using 2 dimentional (2D) electrophoresis analysis, MALDI-TOP, western blot, RT-PCR, and EMSA.
  3. To examine the expressions and functions of proteins related to the differentiation of BMMCs in normal culture system using western blot and RT-PCR methods etc.
  4. To examine the interaction in co-culture of mouse-derived astrocytes and mast cells
  5. To examine pathophysiological mechanism in OVA-induced asthma mouse model exacerbated by smoke exposure
  6. To develop the new drugs for allergic diseases and rheumatoid arthritis from a single component purified from natural materials.

Publications:

  1. DY Kim, SY Ryu, JE Lim, YS Lee, JY Ro: Anti-inflammatory mechanism of simvastatin in mouse allergic asthma model. Eur J Pharmacol, DOI: 10.1016/j.ejphar.2006.11.027 (in press)
  2. JY Kim, DY Kim, YS Lee, BK Lee, KH Kim, JY Ro: DA-9601, Artimissile asiatica Herbal Extract, ameliorates airway inflammation of allergic asthma in mice. Mol cells 22 (1):104-112, 2006
  3. JY Kim, EY Kwon, YS Lee, WB Kim, JY Ro. 2005. Eupatilin blocks mediator release via tyrosine kinase inhibition in activated guinea pig lung mast cells. J Toxicol Environ Health.
  4. JY Kim, KH Lee, BK Lee, JY Ro. 2005. Peroxynitrite modulates release of mediators from guinea pig lung mast cells activated with antigen-antibofy reactions. Int Arch Allergy Immunol137:104-114.
  5. JY Kim, JY Ro. 2005. Signal pathway of cytokines produced by reactive oxygen species generated from PMA-stimulated HMC-1. Scan J Immunol 62:25-35.
  6. BK Lee, JE Yoo, YS Jang, JY Kim, CS Hong, JY Ro. 2004. Allergen-specific immunosuppression by ovalbumin fused with diphtheria toxin in mice sensitized with albumins of different origin. Clin Exp Allergy 34:1642-1648.
  7. YJ Chung, JR Jeoung, BC Lee, JY Kim, YI Park, JY Ro. 2003. Phospholipase D in guinea pig lung tissue membrane is regulated by cytosolic ARF protein. J Microbiol Biotechno13(6):326-332.
  8. Ro JY, Kim JY, Ha JH, Lee CH. 2002. G¥á 12 and G¥á 13 subunits modulate Ca2+-induced histamine release in human umbilical cord blood-derived mast cells. J Microbiol Biotechnol 12(3): 483-489.
  9. Lee KH, Kim JY, Kang DS, Choi YJ, Lee WJ, Ro JY. 2002. Increased expression of endothelial cell adhesion molecules due to mediator release from human foreskin mast cells stimulated by autoantibodies in chronic urticaria sera. J Invest Dermatol 118: 658-663.
  10. Lee BK, Yoo YG, Lee WY, Hong CS, Ro JY. 2001. Ovalbumin fused with Diphtheria toxin protects mice from ovalumin induced anaphylactic shock. Yonsei Med J 41(6): 91-105
  11. JY Ro, JY Kim, KH Kim. 2001. The inhibitory mechanism of rebamipide on the mediator release in the guinea pig lung mast cells activated with specific antigen-antibody reactions. Pharmacology 63:175-184.
  12. JY Ro, BC Lee, JY Kim, MH Chung, SK Lee, KH Kim, YI Park. 2000. The inhibitory mechanism of Aloe single component (Alprogen) on the mediator release in the guinea pig lung mast cells activated with specific antigen-antibody reactions. J Pharmacol Exp Ther 292(1): 114-121.
  13. Kim JY, Kim DY, Lee YS, Lee BK, Lee KH, Ro JY. 2006. DA-9601, Artenisia Asia herbal extract, ameliorates airway inflammation of allergic asthma in mice. Mol Cells 22:113-121.
  14. Kim DY, Ryu SY, Lim JE, Lee YS, Ro JY. 2007. Anti-inflammatory mechanism of simvastatin in mouse allergic asthma model. Eur J Pharmacol 557:76-87.